{"id":7876,"date":"2025-07-20T21:30:23","date_gmt":"2025-07-20T19:30:23","guid":{"rendered":"https:\/\/expandlabs.ro\/?page_id=7876"},"modified":"2025-08-29T17:07:31","modified_gmt":"2025-08-29T15:07:31","slug":"exacta","status":"publish","type":"page","link":"https:\/\/expandlabs.ro\/en\/exacta\/","title":{"rendered":"EXACTA"},"content":{"rendered":"
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

EXACTA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

O solu\u021bie avansat\u0103 de analiz\u0103 molecular-genetic\u0103, personalizat\u0103 pentru a identifica cele mai eficiente tratamente pentru tumorile solide rare \u0219i greu de tratat.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tBook now<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

About Test<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
  • liquid biopsy-type oncology test (minimally invasive, only blood sampling)\u00a0\u201eprecision oncology\u201d<\/strong>, bazat pe biopsie lichid\u0103 (o simpl\u0103 prob\u0103 de s\u00e2nge).<\/li>
  • Analizeaz\u0103 multiple tipuri de biomarkeri:\u00a0celule tumorale circulante (CTC-uri), ADN tumoral circulant (ctDNA), exozomi \u0219i proteine<\/strong>.<\/li>
  • Permite o\u00a0caracterizare molecular\u0103 detaliat\u0103<\/strong>\u00a0a cancerului.<\/li>
  • Identific\u0103\u00a0muta\u021bii genetice<\/strong>, c\u0103i moleculare \u0219i al\u021bi biomarkeri implica\u021bi \u00een progresia tumoral\u0103.<\/li>
  • Integreaz\u0103 rezultatele cu baze de date interna\u021bionale pentru a sugera\u00a0terapii \u021bintite \u0219i imunoterapii<\/strong>\u00a0potrivite fiec\u0103rui pacient.<\/li>
  • Ofer\u0103 medicului un\u00a0raport complex<\/strong>, utilizat pentru alegerea strategiilor de tratament personalizat.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
    \n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    Who is it for?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t
    • Pacien\u021bi oncologici deja diagnostica\u021bi<\/strong>, care au nevoie de o \u00een\u021belegere mai detaliat\u0103 a bolii.<\/li>
    • People looking for\u00a0terapii personalizate<\/strong>\u00a0(terapii \u021bintite, imunoterapie) \u00een func\u021bie de profilul molecular al tumorii.<\/li>
    • Pacien\u021bi \u00een\u00a0stadiu avansat<\/strong>\u00a0sau cu\u00a0recidiv\u0103<\/strong>, unde tratamentele standard nu mai sunt eficiente.<\/li>
    • Pacien\u021bi afla\u021bi sub tratament, pentru\u00a0monitorizarea r\u0103spunsului la terapie<\/strong>\u00a0\u0219i ajustarea planului terapeutic.<\/li>
    • Cazuri \u00een care este nevoie de o\u00a0a doua opinie medical\u0103<\/strong>, bazat\u0103 pe biologie molecular\u0103 \u0219i date validate \u0219tiin\u021bific.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
      \n\t\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t\t\t\t
      \n\t\t\t
      <\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
      \n\t\t\t\t\t
      \n\t\t
      \n\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t\t

      Avantajele testului Exacta<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t\t\t\t\t\t
      • Selec\u021bia cea mai optim\u0103 a terapiei \u021bintite<\/li>
      • Exacta identific\u0103 posibilele \u021binte moleculare \u0219i c\u0103ile ciclului celular pentru a g\u0103si cele mai potrivite \u021binte pentru tratamentul \u021bintit. To\u021bi biomarkerii relevan\u021bi pentru selec\u021bia terapiei \u021bintite, inclusiv muta\u021biile, dele\u021biile, rearanjamentele genice, amplificarea\/expresia genic\u0103, sunt analiza\u021bi.<\/li>
      • Evaluarea reac\u021biilor adverse la medicamente<\/li>
      • Selec\u021bia terapiei cu cele mai pu\u021bine efecte secundare pe baza farmacogenomicii.<\/li>
      • Monitorizarea r\u0103spunsului la tratament \u0219i adaptarea rapid\u0103 a strategiei terapeutice \u00een func\u021bie de modific\u0103rile profilului molecular al tumorii.<\/li>
      • Selec\u021bia cea mai optim\u0103 a terapiei citotoxice<\/li>
      • R\u0103spunsul sau rezisten\u021ba la medicamente citotoxice a genomului cancerului, bazat pe ADN \u0219i expresia genic\u0103. Exacta cuprinz\u0103toare include testarea chimiosensibilit\u0103\u021bii pentru predic\u021bia eficacit\u0103\u021bii medicamentelor citotoxice.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
        \n\t\t\t\t
        \n\t\t\t\t
        \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Expand\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
        \n\t\t\t\t\t
        \n\t\t
        \n\t\t
        \n\t\t\t\t
        \n\t\t\t\t
        \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Cancer\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
        \n\t\t
        \n\t\t\t\t
        \n\t\t\t\t
        \n\t\t\t\t\t

        How does it work?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
        \n\t\t\t\t
        \n\t\t\t\t\t\t\t\t\t
        • Se realizeaz\u0103 prin\u00a0biopsie lichid\u0103<\/strong>\u00a0\u2013 o prob\u0103 simpl\u0103 de s\u00e2nge.<\/li>
        • Analizeaz\u0103\u00a0circulating tumor cells (CTCs)<\/strong>\u00a0and\u00a0ADN tumoral circulant (ctDNA)<\/strong>.<\/li>
        • Identific\u0103\u00a0muta\u021bii genetice, c\u0103i moleculare \u0219i biomarkeri<\/strong>\u00a0relevan\u021bi pentru progresia tumoral\u0103.<\/li>
        • Coreleaz\u0103 informa\u021biile cu baze de date interna\u021bionale \u2192 sugereaz\u0103\u00a0terapii \u021bintite \u0219i imunoterapii<\/strong>\u00a0disponibile.<\/li>
        • Genereaz\u0103 un\u00a0raport detaliat de tip \u201eoncologie de precizie\u201d<\/strong>, pe baza c\u0103ruia medicul poate adapta planul de tratament fiec\u0103rui pacient.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
          \n\t\t\t\t\t
          \n\t\t
          \n\t\t\t\t\t
          \n\t\t
          \n\t\t\t\t
          \n\t\t\t\t
          \n\t\t\t\t\t

          Variante disponibile<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
          \n\t\t\t\t
          \n\t\t\t\t\t\t\t\t\t

          Exacta vine \u00een mai multe op\u021biuni, \u00een func\u021bie de necesit\u0103\u021bile clinice:<\/p>

          • Core \u2192<\/strong>\u00a0evaluare general\u0103 (prezen\u021b\u0103 + muta\u021bii de baz\u0103).<\/li>
          • Comprehensive \u2192<\/strong>\u00a0profil genetic detaliat + recomand\u0103ri de terapii \u021bintite.<\/li>
          • Premium\/Plus \u2192<\/strong>\u00a0caracterizare complet\u0103 + op\u021biuni pentru terapii inovatoare \u0219i monitorizare recidiv\u0103.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
            \n\t\t\t\t\t
            \n\t\t\t\t
            \n\t\t\t\t
            \n\t\t\t\t\t


            Metoda Exacta
            \n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
            \n\t\t\t\t
            \n\t\t\t\t
            \n\t\t\t\t\t\t\t\t\t

            Evaluarea \u021besutului tumoral este utilizat\u0103 at\u00e2t pentru stabilirea diagnosticului, c\u00e2t \u0219i pentru determinarea statusului biomarkerilor relevan\u021bi terapeutic (variante genetice, expresia proteinelor), care ghideaz\u0103 selec\u021bia medicamentelor \u021bintite \u00eempotriva cancerului. Totu\u0219i, o mostr\u0103 de \u021besut ob\u021binut\u0103 prin biopsie reflect\u0103 informa\u021biile la momentul prelev\u0103rii<\/strong> \u0219i nu surprinde evolu\u021bia caracteristicilor moleculare care conduc la rezisten\u021ba la tratament sau la progresia bolii.<\/p>

            De\u0219i medicamentele \u021bintite \u00eempotriva cancerului sunt personalizate \u0219i bazate pe profilarea molecular\u0103 a tumorilor, selec\u021bia agen\u021bilor chimioterapici \u2013 care reprezint\u0103 coloana vertebral\u0103 a regimurilor de tratament \u00een numeroase cancere \u2013 nu se bazeaz\u0103 pe ghidare molecular\u0103<\/strong>. \u00cen prezent, nu exist\u0103 metode prin care s\u0103 se identifice pacien\u021bii la care cancerul este probabil s\u0103 r\u0103spund\u0103 la chimioterapie sau la care tratamentul poate fi ineficient.<\/p>

            Prin urmare, e\u0219ecul tratamentului poate duce la progresia bolii, precum \u0219i la acumularea toxicit\u0103\u021bilor rezultate din tratamente successive ineficiente.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

            \n\t\t\t\t
            \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Expand\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
            \n\t\t\t\t
            \n\t\t\t\t\t\t\t\t\t

            Exacta\u2122<\/strong> reprezint\u0103 o profilare intens\u0103 \u0219i detaliat\u0103 multi-analitic\u0103 a tumorii<\/strong>. Aceasta analizeaz\u0103 milioane de puncte de date la nivel molecular \u0219i func\u021bional pentru a eviden\u021bia vulnerabilit\u0103\u021bi \u0219i amenin\u021b\u0103ri, permi\u021b\u00e2nd identificarea optim\u0103 a \u021bintelor pentru selec\u021bia precis\u0103 a tratamentului.<\/p>

            Exacta\u2122 evalueaz\u0103:<\/p>

            • Variante genetice, cum ar fi muta\u021bii punctuale (SNV \u2013 Single Nucleotide Variants), inser\u021bii \u0219i dele\u021bii, transloca\u021bii, rearanjamente \u0219i fuziuni;<\/p><\/li>

            • Transcrieri genice diferentiate, exprimate mai mult sau mai pu\u021bin;<\/p><\/li>

            • C\u0103i moleculare semnificative activate sau suprimare;<\/p><\/li>

            • Abunden\u021ba proteinelor \u021bint\u0103;<\/p><\/li>

            • Profiluri de chemosensibilitate \/ chemoresisten\u021b\u0103 in vitro<\/strong> ale celulelor tumorale.<\/p><\/li><\/ul>

              Exacta\u2122 este independent\u0103 de determinan\u021bi clasici<\/strong> precum organul primar, subtipul histologic, morfologia (gradul), agresivitatea sau extinderea bolii.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

              \n\t\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t


              FAQ
              <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t
              \n\t\t\t\t\t\t
              \n\t\t\t\t\n\t\t\t\t\t
              Dac\u0103 doi pacien\u021bi au acela\u0219i tip de cancer histopatologic, iar unul dintre ei urmeaz\u0103 analiza Exacta, poate cel\u0103lalt pacient s\u0103 primeasc\u0103 acela\u0219i tratament ca cel indicat pentru primul pacient? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t\t\t

              A\u0219a cum fiecare pacient este unic, la fel \u0219i fiecare cancer. Nici dou\u0103 cancere ale pacien\u021bilor nu sunt identice. Chiar \u0219i doi pacien\u021bi similari (de exemplu v\u00e2rst\u0103, gen, \u00een\u0103l\u021bime, stil de via\u021b\u0103) cu acela\u0219i tip de cancer vor avea profiluri tumorale moleculare diferite. Prin urmare, fiecare pacient ar trebui s\u0103 efectueze un test Exacta individual.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

              \n\t\t\t\t\n\t\t\t\t\t
              De ce este important s\u0103 \u00eencepe\u021bi tratamentul imediat? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t\t\t

              Cancerul poate fi foarte agresiv \u0219i poate evolua rapid; profilul tumoral se poate schimba dramatic \u00een timp. Dac\u0103 exist\u0103 o \u00eent\u00e2rziere suficient de mare, cancerul poate deveni rezistent la tratamente \u0219i poate fi necesar\u0103 o reanaliz\u0103.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

              \n\t\t\t\t\n\t\t\t\t\t
              Ce tip de medicamente vor fi recomandate pacientului? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t\t\t

              Doar medicamente care au fost aprobate de FDA vor fi recomandate \u0219i administrate. Acestea vor include medicamente aprobate de FDA pentru utilizare \u00een acela\u0219i cancer \/ alt tip de cancer \/ alte boli non-canceroase.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

              \n\t\t\t\t\n\t\t\t\t\t
              Exist\u0103 teste moleculare de urm\u0103rire pentru a evalua rezultatul terapiei recomandate? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t\t\t

              Teste moleculare, cum ar fi analiza noastr\u0103 CancerTrack, permit oncologului s\u0103 monitorizeze terapia \u00een timp real. \u00cen plus, testul ofer\u0103 informa\u021bii despre modific\u0103rile genetice ale tumorii originale pentru a adapta terapia.<\/p><\/div><\/div>

              \u00a0<\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

              EXACTA O solu\u021bie avansat\u0103 de analiz\u0103 molecular-genetic\u0103, personalizat\u0103 pentru a identifica cele mai eficiente tratamente pentru tumorile solide rare \u0219i greu de tratat. Rezerv\u0103 acum Despre Test Test oncologic de tip\u00a0\u201eprecision oncology\u201d, bazat pe biopsie lichid\u0103 (o simpl\u0103 prob\u0103 de s\u00e2nge). Analizeaz\u0103 multiple tipuri de biomarkeri:\u00a0celule tumorale circulante (CTC-uri), ADN tumoral circulant (ctDNA), exozomi \u0219i proteine. Permite o\u00a0caracterizare molecular\u0103 detaliat\u0103\u00a0a cancerului. Identific\u0103\u00a0muta\u021bii genetice, c\u0103i moleculare \u0219i al\u021bi biomarkeri implica\u021bi \u00een progresia tumoral\u0103. Integreaz\u0103 rezultatele cu baze de date interna\u021bionale pentru a sugera\u00a0terapii \u021bintite \u0219i imunoterapii\u00a0potrivite fiec\u0103rui pacient. Ofer\u0103 medicului un\u00a0raport complex, utilizat pentru alegerea strategiilor de tratament personalizat. Pentru cine este? Pacien\u021bi oncologici deja diagnostica\u021bi, care au nevoie de o \u00een\u021belegere mai detaliat\u0103 a bolii. Persoane care caut\u0103\u00a0terapii personalizate\u00a0(terapii \u021bintite, imunoterapie) \u00een func\u021bie de profilul molecular al tumorii. Pacien\u021bi \u00een\u00a0stadiu avansat\u00a0sau cu\u00a0recidiv\u0103, unde tratamentele standard nu mai sunt eficiente. Pacien\u021bi afla\u021bi sub tratament, pentru\u00a0monitorizarea r\u0103spunsului la terapie\u00a0\u0219i ajustarea planului terapeutic. Cazuri \u00een care este nevoie de o\u00a0a doua opinie medical\u0103, bazat\u0103 pe biologie molecular\u0103 \u0219i date validate \u0219tiin\u021bific. Avantajele testului Exacta Selec\u021bia cea mai optim\u0103 a terapiei \u021bintite Exacta identific\u0103 posibilele \u021binte moleculare \u0219i c\u0103ile ciclului celular pentru a g\u0103si cele mai potrivite \u021binte pentru tratamentul \u021bintit. To\u021bi biomarkerii relevan\u021bi pentru selec\u021bia terapiei \u021bintite, inclusiv muta\u021biile, dele\u021biile, rearanjamentele genice, amplificarea\/expresia genic\u0103, sunt analiza\u021bi. Evaluarea reac\u021biilor adverse la medicamente Selec\u021bia terapiei cu cele mai pu\u021bine efecte secundare pe baza farmacogenomicii. Monitorizarea r\u0103spunsului la tratament \u0219i adaptarea rapid\u0103 a strategiei terapeutice \u00een func\u021bie de modific\u0103rile profilului molecular al tumorii. Selec\u021bia cea mai optim\u0103 a terapiei citotoxice R\u0103spunsul sau rezisten\u021ba la medicamente citotoxice a genomului cancerului, bazat pe ADN \u0219i expresia genic\u0103. Exacta cuprinz\u0103toare include testarea chimiosensibilit\u0103\u021bii pentru predic\u021bia eficacit\u0103\u021bii medicamentelor citotoxice. Cum func\u021bioneaz\u0103? Se realizeaz\u0103 prin\u00a0biopsie lichid\u0103\u00a0\u2013 o prob\u0103 simpl\u0103 de s\u00e2nge. Analizeaz\u0103\u00a0celule tumorale circulante (CTC-uri)\u00a0\u0219i\u00a0ADN tumoral circulant (ctDNA). Identific\u0103\u00a0muta\u021bii genetice, c\u0103i moleculare \u0219i biomarkeri\u00a0relevan\u021bi pentru progresia tumoral\u0103. Coreleaz\u0103 informa\u021biile cu baze de date interna\u021bionale \u2192 sugereaz\u0103\u00a0terapii \u021bintite \u0219i imunoterapii\u00a0disponibile. Genereaz\u0103 un\u00a0raport detaliat de tip \u201eoncologie de precizie\u201d, pe baza c\u0103ruia medicul poate adapta planul de tratament fiec\u0103rui pacient. Variante disponibile Exacta vine \u00een mai multe op\u021biuni, \u00een func\u021bie de necesit\u0103\u021bile clinice: Core \u2192\u00a0evaluare general\u0103 (prezen\u021b\u0103 + muta\u021bii de baz\u0103). Comprehensive \u2192\u00a0profil genetic detaliat + recomand\u0103ri de terapii \u021bintite. Premium\/Plus \u2192\u00a0caracterizare complet\u0103 + op\u021biuni pentru terapii inovatoare \u0219i monitorizare recidiv\u0103. Metoda Exacta Evaluarea \u021besutului tumoral este utilizat\u0103 at\u00e2t pentru stabilirea diagnosticului, c\u00e2t \u0219i pentru determinarea statusului biomarkerilor relevan\u021bi terapeutic (variante genetice, expresia proteinelor), care ghideaz\u0103 selec\u021bia medicamentelor \u021bintite \u00eempotriva cancerului. Totu\u0219i, o mostr\u0103 de \u021besut ob\u021binut\u0103 prin biopsie reflect\u0103 informa\u021biile la momentul prelev\u0103rii \u0219i nu surprinde evolu\u021bia caracteristicilor moleculare care conduc la rezisten\u021ba la tratament sau la progresia bolii. De\u0219i medicamentele \u021bintite \u00eempotriva cancerului sunt personalizate \u0219i bazate pe profilarea molecular\u0103 a tumorilor, selec\u021bia agen\u021bilor chimioterapici \u2013 care reprezint\u0103 coloana vertebral\u0103 a regimurilor de tratament \u00een numeroase cancere \u2013 nu se bazeaz\u0103 pe ghidare molecular\u0103. \u00cen prezent, nu exist\u0103 metode prin care s\u0103 se identifice pacien\u021bii la care cancerul este probabil s\u0103 r\u0103spund\u0103 la chimioterapie sau la care tratamentul poate fi ineficient. Prin urmare, e\u0219ecul tratamentului poate duce la progresia bolii, precum \u0219i la acumularea toxicit\u0103\u021bilor rezultate din tratamente successive ineficiente. Exacta\u2122 reprezint\u0103 o profilare intens\u0103 \u0219i detaliat\u0103 multi-analitic\u0103 a tumorii. Aceasta analizeaz\u0103 milioane de puncte de date la nivel molecular \u0219i func\u021bional pentru a eviden\u021bia vulnerabilit\u0103\u021bi \u0219i amenin\u021b\u0103ri, permi\u021b\u00e2nd identificarea optim\u0103 a \u021bintelor pentru selec\u021bia precis\u0103 a tratamentului. Exacta\u2122 evalueaz\u0103: Variante genetice, cum ar fi muta\u021bii punctuale (SNV \u2013 Single Nucleotide Variants), inser\u021bii \u0219i dele\u021bii, transloca\u021bii, rearanjamente \u0219i fuziuni; Transcrieri genice diferentiate, exprimate mai mult sau mai pu\u021bin; C\u0103i moleculare semnificative activate sau suprimare; Abunden\u021ba proteinelor \u021bint\u0103; Profiluri de chemosensibilitate \/ chemoresisten\u021b\u0103 in vitro ale celulelor tumorale. Exacta\u2122 este independent\u0103 de determinan\u021bi clasici precum organul primar, subtipul histologic, morfologia (gradul), agresivitatea sau extinderea bolii. FAQ Dac\u0103 doi pacien\u021bi au acela\u0219i tip de cancer histopatologic, iar unul dintre ei urmeaz\u0103 analiza Exacta, poate cel\u0103lalt pacient s\u0103 primeasc\u0103 acela\u0219i tratament ca cel indicat pentru primul pacient? A\u0219a cum fiecare pacient este unic, la fel \u0219i fiecare cancer. Nici dou\u0103 cancere ale pacien\u021bilor nu sunt identice. Chiar \u0219i doi pacien\u021bi similari (de exemplu v\u00e2rst\u0103, gen, \u00een\u0103l\u021bime, stil de via\u021b\u0103) cu acela\u0219i tip de cancer vor avea profiluri tumorale moleculare diferite. Prin urmare, fiecare pacient ar trebui s\u0103 efectueze un test Exacta individual. De ce este important s\u0103 \u00eencepe\u021bi tratamentul imediat? Cancerul poate fi foarte agresiv \u0219i poate evolua rapid; profilul tumoral se poate schimba dramatic \u00een timp. Dac\u0103 exist\u0103 o \u00eent\u00e2rziere suficient de mare, cancerul poate deveni rezistent la tratamente \u0219i poate fi necesar\u0103 o reanaliz\u0103. Ce tip de medicamente vor fi recomandate pacientului? Doar medicamente care au fost aprobate de FDA vor fi recomandate \u0219i administrate. Acestea vor include medicamente aprobate de FDA pentru utilizare \u00een acela\u0219i cancer \/ alt tip de cancer \/ alte boli non-canceroase. Exist\u0103 teste moleculare de urm\u0103rire pentru a evalua rezultatul terapiei recomandate? Teste moleculare, cum ar fi analiza noastr\u0103 CancerTrack, permit oncologului s\u0103 monitorizeze terapia \u00een timp real. \u00cen plus, testul ofer\u0103 informa\u021bii despre modific\u0103rile genetice ale tumorii originale pentru a adapta terapia. \u00a0 A\u0219a cum fiecare pacient este unic, la fel \u0219i fiecare cancer. Nici dou\u0103 cancere ale pacien\u021bilor nu sunt identice. Chiar \u0219i doi pacien\u021bi similari (de exemplu v\u00e2rst\u0103, gen, \u00een\u0103l\u021bime, stil de via\u021b\u0103) cu acela\u0219i tip de cancer vor avea profiluri tumorale moleculare diferite. Prin urmare, fiecare pacient ar trebui s\u0103 efectueze un test Exacta individual. Cancerul poate fi foarte agresiv \u0219i poate evolua rapid; profilul tumoral se poate schimba dramatic \u00een timp. Dac\u0103 exist\u0103 o \u00eent\u00e2rziere suficient de mare, cancerul poate deveni rezistent la tratamente \u0219i poate fi necesar\u0103 o reanaliz\u0103. Doar medicamente care au fost aprobate de FDA vor fi recomandate \u0219i administrate. Acestea vor include medicamente aprobate de FDA pentru utilizare \u00een acela\u0219i cancer \/ alt tip de cancer \/ alte boli non-canceroase. Teste moleculare, cum ar fi analiza noastr\u0103 CancerTrack, permit oncologului s\u0103 monitorizeze terapia \u00een timp real. \u00cen plus, testul ofer\u0103 informa\u021bii despre modific\u0103rile genetice ale tumorii originale pentru a adapta terapia. \u00a0<\/p>","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-7876","page","type-page","status-publish","hentry"],"blocksy_meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/pages\/7876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/comments?post=7876"}],"version-history":[{"count":72,"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/pages\/7876\/revisions"}],"predecessor-version":[{"id":9017,"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/pages\/7876\/revisions\/9017"}],"wp:attachment":[{"href":"https:\/\/expandlabs.ro\/en\/wp-json\/wp\/v2\/media?parent=7876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}